San Antonio’s deep history is contrasted with its fast growth over the previous few decades. It was the quickest-expanding of the leading ten biggest cities in the United States from 2000 to 2010, and the second from 1990 to 2000. Straddling the regional divide in between South and Central Texas, San Antonio anchors the southwestern corner of an urban megaregion colloquially known as the “Texas Triangle”. The Better San Antonio and Better Austin areas are separated from every other by a few miles along Interstate 35 in between New Braunfels, Texas and San Marcos, Texas. Despite the two metros becoming so close, it is one particular of the few areas in the United States without an official Combined Statistical Location issued by the census bureau.
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San Antonio serves as the seat of Bexar County current annexations have extended the city’s boundaries into Medina County and, for a tiny area near the city of Backyard Ridge, into Comal County. Since San Antonio was founded for the duration of the Spanish Colonial Era, it has a church (San Fernando Cathedral) in its center, on the principal civic plaza in front, a characteristic of many Spanish-founded cities, towns, and villages in Spain and Latin America. As with many other urban centers in the Southern United States, areas outside the city limits are sparsely populated.
San Antonio is the center of the San Antonio–New Braunfels metropolitan statistical area. Frequently called Better San Antonio, the metro area has a population of two,473,974 primarily based on the 2017 U.S. census estimate, creating it the 24th-biggest metropolitan area in the United States and third-biggest in Texas. Development along the Interstate 35 and Interstate ten corridors to the north, west and east make it likely that the metropolitan area will carry on to increase.
San Antonio was named by a 1691 Spanish expedition for Saint Anthony of Padua, whose feast day is June 13. The city includes 5 18th-century Spanish frontier missions, such as The Alamo and San Antonio Missions National Historical Park, which with each other were designated UNESCO Globe Heritage web sites in 2015. Other notable points of interest consist of the River Stroll, the Tower of the Americas, SeaWorld, the Alamo Bowl, and Marriage Island. Commercial entertainment consists of 6 Flags Fiesta Texas and Morgan’s Wonderland amusement parks. In accordance to the San Antonio Convention and Guests Bureau, the city is visited by about 32 million visitors a yr. It is property to the 5-time NBA champion San Antonio Spurs, and hosts the annual San Antonio Stock Demonstrate & Rodeo, one particular of the biggest such events in the U.S.
The U.S. Armed Forces have quite a few services in and close to San Antonio Fort Sam Houston is the only one particular inside of the city limits. Lackland Air Force Base, Randolph Air Force Base, Lackland AFB/Kelly Field Annex, Camp Bullis, and Camp Stanley are outside the city limits. Kelly Air Force Base operated out of San Antonio until finally 2001, when the airfield was transferred to Lackland AFB. The remaining components of the base were created as Port San Antonio, an industrial/business park and aerospace complex. San Antonio is property to 6 Fortune 500 companies and the South Texas Health-related Center, the only health-related analysis and care supplier in the South Texas region.
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San Diego has been referred to as “the birthplace of California”. Historically home to the Kumeyaay individuals, it was the very first website visited by Europeans on what is now the West Coast of the United States. On landing in San Diego Bay in 1542, Juan Rodríguez Cabrillo claimed the region for Spain, forming the basis for the settlement of Alta California 200 many years later. The Presidio and Mission San Diego de Alcalá, founded in 1769, formed the very first European settlement in what is now California. In 1821, San Diego grew to become element of the newly declared Mexican Empire, which reformed as the Initial Mexican Republic two many years later. California grew to become element of the United States in 1848 following the Mexican–American War and was admitted to the union as a state in 1850.
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The Jeep has been widely imitated all around the planet, such as in France by Delahaye and by Hotchkiss et Cie (soon after 1954, Hotchkiss produced Jeeps under license from Willys), and in Japan by Mitsubishi Motors and Toyota. The Land Rover was inspired by the Jeep. The utilitarian good seems of the authentic Jeep have been hailed by industrial designers and museum curators alike. The Museum of Modern day Art described the Jeep as a masterpiece of functionalist layout, and has periodically exhibited the Jeep as portion of its assortment. Pulitzer Prize-winning war correspondent Ernie Pyle named the jeep, along with the Coleman G.I. Pocket Stove, “the two most important pieces of noncombat tools ever produced.” Jeeps became even much more well-known following the war, as they became offered on the surplus marketplace. Some advertisements claimed to provide “Jeeps nevertheless in the factory crate.” This legend persisted for decades, regardless of the reality that Jeeps had been never shipped from the factory in crates (though Ford did “knock down” Jeeps for less complicated shipping, which might have perpetuated the myth).
The Jeepney is a exclusive variety of taxi or bus designed in the Philippines. The 1st Jeepneys had been military-surplus MBs and GPWs, left behind in the war-ravaged country following Globe War II and Filipino independence. Jeepneys had been constructed from Jeeps by lengthening and widening the rear “tub” of the vehicle, permitting them to carry much more passengers. In excess of the many years, Jeepneys have grow to be the most ubiquitous symbol of the modern Philippines, even as they have been decorated in much more elaborate and flamboyant designs by their owners. Most Jeepneys right now are scratch-constructed by local makers, making use of distinct powertrains.
Aside from Jeepneys, backyard assemblers in the Philippines construct replica Jeeps with stainless steel bodies and surplus elements, and are named “owner-variety jeeps” (as jeepneys are also named “passenger-variety jeeps”). Jeeps are also used for Moab jeep tours, Moab jeep rentals, and Jeep organization tours.
In the United States military, the Jeep has been supplanted by a number of vehicles (e.g. Ford’s M151) of which the most recent is the Humvee.
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San Francisco was founded on June 29, 1776, when colonists from Spain established Presidio of San Francisco at the Golden Gate and Mission San Francisco de Asís a number of miles away, all named for St. Francis of Assisi. The California Gold Rush of 1849 brought speedy development, creating it the greatest city on the West Coast at the time. San Francisco grew to become a consolidated city-county in 1856. San Francisco’s status as the West Coast’s greatest city peaked among 1870 and 1900, when about 25% of California’s population resided in the city correct. Right after three-quarters of the city was destroyed by the 1906 earthquake and fire, San Francisco was rapidly rebuilt, internet hosting the Panama-Pacific Worldwide Exposition nine years later. In World War II, San Francisco was a major port of embarkation for support members shipping out to the Pacific Theater. It then grew to become the birthplace of the United Nations in 1945. Right after the war, the confluence of returning servicemen, important immigration, liberalizing attitudes, along with the rise of the “hippie” counterculture, the Sexual Revolution, the Peace Motion expanding from opposition to United States involvement in the Vietnam War, and other aspects led to the Summertime of Love and the gay rights movement, cementing San Francisco as a center of liberal activism in the United States. Politically, the city votes strongly along liberal Democratic Celebration lines.
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Jeep is a brand of American car and division of FCA US LLC (formerly Chrysler Group, LLC), a wholly owned subsidiary of the Italian-American corporation Fiat Chrysler Automobiles. Jeep has been a part of Chrysler considering that 1987, when Chrysler acquired the Jeep rock sliders brand, along with remaining assets, from its prior proprietor American Motors Corporation (AMC).
Jeep’s current item selection consists solely of sport utility cars and off-road cars, but has also included pickup trucks and roadsters in the previous Jeep bumpers returned to the pickup truck marketplace in early 2019. Some of Jeep’s vehicles—such as the Grand Cherokee—reach into the luxury SUV segment, a marketplace segment the Wagoneer is regarded as to have produced. Jeep sold one.four million SUVs globally in 2016, up from 500,000 in 2008, two-thirds of which in North America, and was Fiat-Chrysler’s very best selling brand in the U.S. throughout the very first half of 2017. In the U.S. alone, over 2400 dealerships hold franchise rights to promote Jeep-branded cars, and if Jeep had been spun off into a separate company, it is estimated to be worth between $22 and $33.5 billion—slightly far more than all of FCA (US).
Prior to 1940 the phrase “jeep” had been utilized as U.S. Army slang for new recruits or cars, but the Planet War II “jeep” that went into production in 1941 especially tied the identify to this light military 4×4, arguably producing them the oldest four-wheel drive mass-production cars now recognized as SUVs. The Jeep grew to become the primary light four-wheel-drive automobile of the United States Army and the Allies throughout Planet War II, as nicely as the postwar period. The phrase grew to become frequent throughout the world in the wake of the war. Doug Stewart mentioned: “The spartan, cramped, and unstintingly practical jeep grew to become the ubiquitous Planet War II four-wheeled personification of Yankee ingenuity and cocky, can-do determination.” It is the precursor of subsequent generations of military light utility cars this kind of as the Humvee, and inspired the creation of civilian analogs this kind of as the authentic Series I Land Rover. Several Jeep variants serving similar military and civilian roles have considering that been designed in other nations.
The Jeep marque has been headquartered in Toledo, Ohio, ever considering that Willys-Overland launched production of the very first CJ or Civilian Jeep branded versions there in 1945. Its replacement, the conceptually constant Jeep Wrangler series, stays in production considering that 1986. With its sound axles and open top, the Wrangler has been referred to as the Jeep off-road accessories model that is as central to the brand’s identity as the rear-engined 911 is to Porsche.
At least two Jeep versions (the CJ-5 and the SJ Wagoneer) appreciated extraordinary 3-decade production runs of a single body generation.
In lowercase, the phrase “jeep” continues to be utilized as a generic phrase for cars inspired by the Jeep that are appropriate for use on rough terrain.
San Jose is a international city, notable as a center of innovation, for its affluence, Mediterranean climate, and extremely large cost of living. San Jose’s area inside the booming large tech market, as a cultural, political, and economic center has earned the city the nickname “Capital of Silicon Valley”. San Jose is one of the wealthiest major cities in the United States and the globe, and has the third highest GDP per capita in the globe (right after Zürich, Switzerland and Oslo, Norway), in accordance to the Brookings Institution. The San Jose Metropolitan Region has the most millionaires and the most billionaires in the United States per capita. With a median residence price of $1,085,000, San Jose has the most costly housing industry in the nation and the fifth most costly housing industry in the globe, in accordance to the 2017 Demographia International Housing Affordability Survey. Major international tech businesses which includes Cisco Methods, eBay, Adobe Methods, PayPal, Broadcom, Samsung, Acer, Hewlett Packard Enterprise, and Western Digital keep their headquarters in San Jose, in the center of Silicon Valley.
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Just before the arrival of the Spanish, the region close to San Jose was inhabited by the Tamien nation of the Ohlone peoples of California. San Jose was founded on November 29, 1777, as the Pueblo de San José de Guadalupe, the 1st city founded in the Californias. It then became a element of Mexico in 1821 right after the Mexican War of Independence. Following the American Conquest of California throughout the Mexican–American War, the territory was ceded to the United States in 1848. After California accomplished statehood two many years later, San Jose became the state’s 1st capital. Following Planet War II, San Jose skilled an economic boom, with a fast population development and aggressive annexation of nearby cities and communities carried out in the 1950s and 1960s. The fast development of the large-technology and electronics industries more accelerated the transition from an agricultural center to an urbanized metropolitan region. Outcomes of the 1990 U.S. Census indicated that San Jose had officially surpassed San Francisco as the most populous city in Northern California. By the 1990s, San Jose and the rest of Silicon Valley had become the international center for the large tech and net industries, producing it California’s fastest-growing economy.
There are three recognized accessible sources of autologous adult stem cells in people: bone marrow, adipose tissue, and blood. Stem cells can also be taken from umbilical cord blood just soon after birth. Of all stem cell treatment kinds, autologous harvesting requires the least risk.
Grownup stem cells are often used in a variety of medical therapies (e.g., bone marrow transplantation). Stem cells can now be artificially grown and transformed (differentiated) into specialized cell kinds with characteristics constant with cells of a variety of tissues this kind of as muscle tissue or nerves. Embryonic cell lines and autologous embryonic stem cells produced via somatic cell nuclear transfer or dedifferentiation have also been proposed as promising candidates for long term therapies. Study into stem cells grew out of findings by Ernest A. McCulloch and James E. Until at the University of Toronto in the 1960s.
Stem cells are cells with the likely to create into several diverse kinds of cells in the body. They serve as a fix method for the body. There are two major kinds of stem cells: embryonic stem cells and adult stem cells.
Stem cells are diverse from other cells in the body in three methods:
- They can divide and renew themselves more than a prolonged time
- They are unspecialized, so they are not able to do distinct functions in the body
- They have the likely to turn out to be specialized cells, this kind of as muscle cells, blood cells, and brain cells
Doctors and scientists are thrilled about stem cells due to the fact they could assist in several diverse areas of wellness and medical research. Studying stem cells could assist clarify how critical circumstances this kind of as birth defects and cancer come about. Stem cells could one particular day be used to make cells and tissues for treatment of several conditions. Examples include Parkinson’s condition, Alzheimer’s condition, spinal cord injury, heart condition, diabetes, and arthritis.
How can stem cells deal with condition?
When most men and women consider about about stem cells treating condition they consider of a stem cell transplant.
In a stem cell transplant, embryonic stem cells are 1st specialized into the required adult cell variety. Then, people mature cells exchange tissue that is damaged by condition or injury. This variety of treatment method could be used to:
- exchange neurons damaged by spinal cord injury, stroke, Alzheimer’s condition, Parkinson’s condition or other neurological difficulties
- create insulin that could deal with men and women with diabetes and heart muscle cells that could fix injury soon after a heart assault or
- exchange nearly any tissue or organ that is injured or diseased.
But embryonic stem cell-based mostly therapies can do significantly far more.
- Studying how stem cells create into heart muscle cells could supply clues about how we could induce heart muscle to fix itself soon after a heart assault.
- The cells could be used to research condition, identify new medication, or display medication for toxic side results.
Any of these would have a significant influence on human wellness with out transplanting a single cell.
In theory, there is no restrict to the kinds of conditions that could be handled with stem cell research. Offered that researchers could be able to research all cell kinds by means of embryonic stem cells, they have the likely to make breakthroughs in any condition.
CIRM has designed condition pages for several of the significant conditions currently being targeted by stem cell scientists. You can uncover people condition pages right here.
You can also sort our full record of CIRM awards to see what we have funded in diverse condition areas.
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Seattle is situated on an isthmus among Puget Sound (an inlet of the Pacific Ocean) and Lake Washington, about one hundred miles (160 km) south of the Canada–United States border. A big gateway for trade with Asia, Seattle is the fourth-largest port in North America in terms of container managing as of 2015.
The Seattle area was inhabited by Native Americans for at least 4,000 years before the initial everlasting European settlers. Arthur A. Denny and his group of vacationers, subsequently acknowledged as the Denny Get together, arrived from Illinois by way of Portland, Oregon, on the schooner Exact at Alki Level on November 13, 1851. The settlement was moved to the eastern shore of Elliott Bay and named “Seattle” in 1852, in honor of Chief Si’ahl of the area Duwamish and Suquamish tribes. Right now, Seattle has high populations of Native, Scandinavian, African, and Asian Americans, as well as a thriving LGBT community that ranks 6th in the United States for population.
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Logging was Seattle’s initial big sector, but by the late 19th century, the city had develop into a commercial and shipbuilding center as a gateway to Alaska during the Klondike Gold Rush. Development immediately after Globe War II was partially due to the area Boeing organization, which established Seattle as a center for aircraft manufacturing. The Seattle area formulated into a engineering center from the 1980s onwards with businesses like Microsoft getting to be established in the region Microsoft founder Bill Gates is a Seattleite by birth. Web retailer Amazon was founded in Seattle in 1994, and big airline Alaska Airlines is based mostly in SeaTac, Washington, serving Seattle’s worldwide airport, Seattle–Tacoma Global Airport. The stream of new software, biotechnology, and Web businesses led to an financial revival, which improved the city’s population by just about 50,000 among 1990 and 2000. Owing largely to its quickly expanding population in the 21st century, Seattle and the state of Washington have some of the highest minimum wages in the country, at $15 per hour for smaller sized firms and $16 for the city’s largest employers.